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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Updated: Mar 21, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
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Noncoding Regulatory RNAs in Hematopoiesis.

M Jeong1, M A Goodell1

  • 1Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, United States.

Current Topics in Developmental Biology
|May 4, 2016
PubMed
Summary
This summary is machine-generated.

Regulatory noncoding RNAs (ncRNAs) are newly discovered regulators of hematopoietic stem cell (HSC) self-renewal and differentiation. Understanding these ncRNAs offers insights into blood development and hematologic malignancies.

Keywords:
Antisense noncoding transcriptsErythropoiesisHematopoiesisHematopoietic malignanciesHematopoietic stem cellsLymphopoiesisMyelopoiesiseRNAslncRNAs

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Area of Science:

  • Molecular Biology
  • Genetics
  • Hematology

Background:

  • Hematopoiesis, the generation of blood cells from hematopoietic stem cells (HSCs), is a complex process.
  • While protein-coding genes are known regulators, additional regulatory layers in HSC fate remain underexplored.
  • Recent advances in deep sequencing have identified novel classes of regulatory noncoding RNAs (ncRNAs).

Purpose of the Study:

  • To review recent advances in understanding functional regulatory ncRNAs in hematopoiesis.
  • To highlight the role of ncRNAs in hematopoietic stem cell self-renewal and differentiation.
  • To discuss dysregulated ncRNAs implicated in hematologic malignancies.

Main Methods:

  • Literature review of recent studies on noncoding RNAs in hematopoiesis.
  • Analysis of functional roles of ncRNAs, including enhancer RNAs and antisense ncRNAs.
  • Examination of ncRNA involvement in hematopoietic development and diseases.

Main Results:

  • Noncoding RNAs represent a significant, previously underappreciated layer of HSC regulation.
  • Specific ncRNAs have been functionally linked to key processes of hematopoietic self-renewal and differentiation.
  • Aberrant expression of certain ncRNAs is associated with the development of hematologic malignancies.

Conclusions:

  • Regulatory ncRNAs are crucial for normal hematopoietic processes.
  • Further investigation of ncRNAs will deepen our understanding of blood development and related diseases.
  • Targeting ncRNAs may offer novel therapeutic strategies for hematologic malignancies.