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Updated: Mar 21, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
[Alpha-Radioimmunotherapy: principle and relevance in anti-tumor immunity]
Jérémie Ménager1, Jean-Baptiste Gorin1, Nolwenn Fichou1
1Centre de Recherche en Cancérologie Nantes/Angers (CRCNA) - UMR 892 Inserm, 8, quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France - 6299 CNRS, Nantes, France - Université de Nantes, Nantes, France.
Abstract:
Alpha-radioimmunotherapy (α-RIT) is a targeted anti-tumor therapy using usually a monoclonal antibody specific for a tumor antigen that is coupled to an α-particle emitter. α-emitters represent an ideal tool to eradicate disseminated tumors or metastases. Recent data demonstrate that ionizing radiation in addition to its direct cytotoxic ability can also induce an efficient anti-tumor immunity. This suggests that biologic effects on irradiated tissues could be used to potentiate immunotherapy efficacy and opens the way for development of new therapies combining α-RIT and different types of immunotherapy.
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