Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

1.3K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.3K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

75
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
75
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

86
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
86
Pharmacogenetics of Drug Metabolism: Overview01:27

Pharmacogenetics of Drug Metabolism: Overview

102
Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...
102
Multiple Allele Traits01:49

Multiple Allele Traits

38.6K
The Concept of Multiple Allelism
38.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide association study identifies a novel locus for cannabis dependence.

Molecular psychiatry·2017
Same author

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.

Molecular psychiatry·2017
Same author

Structural alterations within cerebellar circuitry are associated with general liability for common mental disorders.

Molecular psychiatry·2017
Same author

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.

Molecular psychiatry·2017
Same author

The association between cognitive function and subsequent depression: a systematic review and meta-analysis.

Psychological medicine·2016
Same author

Evidence of CNIH3 involvement in opioid dependence.

Molecular psychiatry·2015

Related Experiment Video

Updated: Mar 21, 2026

Quantifying Social Motivation in Mice Using Operant Conditioning
07:43

Quantifying Social Motivation in Mice Using Operant Conditioning

Published on: August 8, 2015

19.1K

COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis.

N S Corral-Frías1,2, D A Pizzagalli3, J M Carré4

  • 1Psychiatry Department, Washington University in St. Louis, St. Louis, MO, USA.

Genes, Brain, and Behavior
|May 4, 2016
PubMed
Summary

Individual differences in reward learning are influenced by dopamine signaling. The COMT rs4680 genotype, specifically the Met allele homozygosity, is linked to enhanced reward learning, potentially impacting psychopathology.

Keywords:
AnhedoniaCOMTdopaminemeta-analysisresponse biasreward

More Related Videos

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.9K
Studying Food Reward and Motivation in Humans
12:09

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

24.3K

Related Experiment Videos

Last Updated: Mar 21, 2026

Quantifying Social Motivation in Mice Using Operant Conditioning
07:43

Quantifying Social Motivation in Mice Using Operant Conditioning

Published on: August 8, 2015

19.1K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.9K
Studying Food Reward and Motivation in Humans
12:09

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

24.3K

Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Psychology

Background:

  • Individual differences in reward learning are crucial for understanding adaptive behaviors and psychopathology.
  • Variability in dopaminergic reinforcement signaling is a candidate mechanism influencing reward learning.
  • The catechol-O-methyl transferase (COMT) gene rs4680 polymorphism (Val158Met) affects dopamine levels and has been linked to reward learning.

Purpose of the Study:

  • To investigate the association between the COMT rs4680 genotype and individual differences in reward learning.
  • To replicate and confirm prior findings on the role of COMT rs4680 in reward learning.
  • To explore potential etiological pathways for psychopathology related to reward dysfunction.

Main Methods:

  • Utilized a probabilistic reward learning task to assess response bias in three combined samples (N=392).
  • Genotyped participants for the COMT rs4680 polymorphism (Val158Met).
  • Conducted a meta-analysis of four studies, including the current one, to confirm the association.

Main Results:

  • Replicated the finding that COMT rs4680 Met allele homozygosity is associated with increased reward learning in European-American participants (β = 0.20, P < 0.01).
  • Meta-analysis of four studies confirmed a significant association between COMT rs4680 genotype and reward learning (P < 0.01).
  • Results indicate that dopamine signaling variability, influenced by COMT rs4680, contributes to individual differences in reward learning.

Conclusions:

  • Dopamine signaling variability, as modulated by the COMT rs4680 polymorphism, significantly influences individual differences in reward learning.
  • These findings suggest a potential genetic contribution to reward dysfunction observed in various psychopathologies.
  • Understanding these mechanisms can inform research into adaptive responding and maladaptive behaviors.