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Updated: Mar 21, 2026
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Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
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Lactate dehydrogenase in sickle cell disease.
Katia Stankovic Stojanovic1, François Lionnet1
1Centre de référence adulte de la drépanocytose, service de médecine interne, hôpital Tenon, Assistance publique-hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France.
Summary
Lactate dehydrogenase (LDH) levels are often high in sickle cell disease (SCD) due to red blood cell breakdown and tissue damage. This review examines how LDH activity relates to SCD complications.
Area of Science:
- Biochemistry
- Hematology
- Pathophysiology
Background:
- Lactate dehydrogenase (LDH) activity is a marker for cellular damage and is elevated in various diseases.
- Sickle cell disease (SCD) involves complex pathophysiological processes impacting multiple organ systems.
- Understanding LDH's role in SCD is crucial for managing disease progression and complications.
Purpose of the Study:
- To review and evaluate existing literature on lactate dehydrogenase (LDH) activity in sickle cell disease (SCD).
- To explore the relationship between LDH levels and both steady-state and acute conditions in SCD patients.
Main Methods:
- Literature review of studies examining LDH activity in sickle cell disease.
- Analysis of data pertaining to LDH levels during steady-state and acute SCD episodes.
Main Results:
- Elevated LDH activity in SCD is primarily linked to intravascular hemolysis.
- LDH elevation also results from ischemia-reperfusion injury and tissue necrosis in SCD.
- LDH serves as a diagnostic and prognostic indicator for SCD complications.
Conclusions:
- LDH is a significant biomarker in sickle cell disease, reflecting hemolysis and tissue damage.
- Monitoring LDH activity can aid in assessing disease severity and predicting complications in SCD.
- Further research into LDH's role can refine diagnostic and therapeutic strategies for SCD.
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