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Lactate dehydrogenase in sickle cell disease

Katia Stankovic Stojanovic1, François Lionnet1

  • 1Centre de référence adulte de la drépanocytose, service de médecine interne, hôpital Tenon, Assistance publique-hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|May 4, 2016
PubMed

Lactate dehydrogenase (LDH) activity is elevated in many pathological states. Interest in LDH activity in sickle cell disease (SCD) has developed out of an increased comprehension of the pathophysiological process and the clinical course of the disease. Elevated LDH activity in SCD comes from various mechanisms, especially intravascular hemolysis, as well as ischemia-reperfusion damage and tissular necrosis. Intravascular hemolysis is associated with vasoconstriction, platelet activation, endothelial damage, and vascular complications. LDH has been used as a diagnostic and prognostic factor of acute and chronic complications. In this review we have evaluated the literature where LDH activity was examined during steady-state or acute conditions in SCD.

Keywords:
HemolysisLactate dehydrogenasePrognosisSickle cell disease

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