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Cardiac thrombus with risk of fulminant pulmonary embolism in paediatric antiphospholipid syndrome

M Albinski1, M Hufnagel2, J Schelling2

  • 1Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Freiburg, Freiburg.

Klinische Padiatrie
|May 4, 2016
PubMed

Insights

Antiphospholipid Syndrome (APS) can cause dangerous blood clots in children. A rare case highlights a 15-year-old with deep vein thrombosis and a tumor that was actually a thrombus, leading to a full recovery.

Area of Science:

  • Cardiology
  • Hematology
  • Immunology

Background:

  • Antiphospholipid Syndrome (APS) is a systemic autoimmune disorder characterized by autoantibodies targeting membrane components.
  • APS involves coagulation pathways, complement factors, and immune cells, leading to thrombosis in various blood vessels.
  • Clinical manifestations of APS are diverse, depending on the affected organ, with limited data available for pediatric cases.

Observation:

  • A 15-year-old patient presented with deep vein thrombosis and a right ventricular tumor.
  • The tumor posed a significant risk of a life-threatening pulmonary embolism.
  • Surgical removal of the mass was performed.

Findings:

  • Histological examination confirmed the right ventricular mass to be a thrombus.
  • The patient experienced a complete recovery following surgical intervention.
  • Long-term anticoagulation therapy was initiated for the patient.

Implications:

  • This case underscores the importance of considering thrombotic events in pediatric patients presenting with unusual masses.
  • Early diagnosis and appropriate management, including surgical removal and anticoagulation, are crucial for favorable outcomes in pediatric APS.
  • Further research into pediatric APS is warranted to improve understanding and treatment strategies.

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