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Published on: March 15, 2018
MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases
Haowei Li1, Zanjing Zhai1, Xinhua Qu1
1Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
Background:
Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.
Objective:
The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.
Results:
There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.
Conclusion:
Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.
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