Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Pilocarpine administration by contact lens.

V J Marmion, S Yurdakul

Transactions of the Ophthalmological Societies of the United Kingdom

|April 1, 1977

Summary

Hydrophilic contact lenses deliver pilocarpine to the eye more effectively than drops or injections, achieving higher concentrations in the iris and ciliary body for better intraocular pressure control.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Frequent oral ulceration during early disease may predict a severe disease course in males with Behçet's syndrome.

Clinical and experimental rheumatology·2012

Same author

Evaluation of the morphological effects of TDT 067 (terbinafine in Transfersome) and conventional terbinafine on dermatophyte hyphae in vitro and in vivo.

Antimicrobial agents and chemotherapy·2012

Same author

Clinical implications of velocity vector imaging-based two dimensional strain imaging for the evaluation of left ventricular systolic functions.

Minerva cardioangiologica·2010

Same author

Relapsing polychondritis in a patient with familial Mediterranean fever and amyloidosis.

Clinical and experimental rheumatology·2008

Same author

Management of Behçet disease: a systematic literature review for the European League Against Rheumatism evidence-based recommendations for the management of Behçet disease.

Annals of the rheumatic diseases·2008

Same author

EULAR recommendations for the management of Behçet disease.

Annals of the rheumatic diseases·2008

Area of Science:

Ophthalmology
Pharmacology
Drug Delivery Systems

Background:

Previous studies suggested hydrophilic contact lenses enhance pilocarpine delivery for intraocular pressure control.
Optimizing pilocarpine delivery is crucial for managing glaucoma and related conditions.

Purpose of the Study:

To compare the ocular distribution and concentration of pilocarpine delivered via hydrophilic contact lenses, eye drops, and subconjunctival injection in an animal model.
To further elucidate the pharmacokinetic advantages of contact lens-mediated pilocarpine delivery.

Main Methods:

Radioactive-labeled pilocarpine was used to quantify drug concentration in ocular tissues.
Three administration methods were compared: hydrophilic contact lens, topical eye drops, and subconjunctival injection.
Concentrations of pilocarpine in the iris, ciliary body, and conjunctiva were measured.

Main Results:

Contact lens delivery resulted in significantly higher pilocarpine concentrations in the iris and ciliary body compared to drops and subconjunctival injection.
Drop administration led to high pilocarpine concentration in the conjunctiva, comparable to subconjunctival injection.
Subconjunctival injection showed comparable conjunctival concentrations to drops but lower iris/ciliary body concentrations than contact lenses.

Conclusions:

Hydrophilic contact lenses offer a superior method for delivering pilocarpine to the anterior ocular tissues, specifically the iris and ciliary body.
This enhanced delivery via contact lenses may translate to improved efficacy in managing intraocular pressure.
Topical drop administration primarily increases conjunctival drug levels, with less efficient penetration to target ocular structures compared to contact lenses.

Related Experiment Videos