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Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications.
Predrag Sikiric1, Sven Seiwerth, Rudolf Rucman
1Medical Faculty, University of Zagreb, Šalata 3, 10000 Zagreb, Croatia.
Current Neuropharmacology
|May 4, 2016
Summary
Stable gastric pentadecapeptide BPC 157, a potent antiulcer agent, demonstrates significant therapeutic potential for central nervous system (CNS) disorders by modulating neurotransmitter systems and offering neuroprotection.
Area of Science:
- Neurogastroenterology
- Peptide Science
- Central Nervous System (CNS) Disorders
Background:
- Brain-gut interaction involves peptidergic growth factors with antiulcer properties.
- Stable gastric pentadecapeptide BPC 157 is a native GI peptide with demonstrated safety in clinical trials.
- BPC 157's antiulcer potency suggests potential peripheral benefits for CNS disorders.
Purpose of the Study:
- To review research on the stable gastric pentadecapeptide BPC 157 concerning the brain-gut axis.
- To explore BPC 157's therapeutic potential in CNS disorders.
Main Methods:
- Review of existing research data on BPC 157.
- Analysis of BPC 157's effects on the brain-gut axis and CNS functions.
Main Results:
- BPC 157 acts as a cytoprotective agent, maintaining GI mucosa integrity without toxicity.
- BPC 157 shows efficacy in treating various GI, liver, and pancreas lesions, and promotes tissue healing.
- BPC 157 modulates central serotonergic and dopaminergic systems, improves behavioral disturbances, and exerts neuroprotective effects, including nerve regeneration and recovery from TBI and spinal cord injury.
Conclusions:
- BPC 157, a gastric peptide, shows promise as a therapeutic agent for diverse CNS disorders.
- Its ability to modulate neurotransmitter systems and protect neural tissues supports its potential in treating neurological conditions.
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