Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

249
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
249
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

331
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
331
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

19.5K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
19.5K
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

4.8K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.8K
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug01:14

Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug

289
In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...
289
Liver Physiology01:30

Liver Physiology

4.2K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural diversity-guided catalytic-core chimerism engineers a rapid and inhibitor-tolerant reverse transcriptase.

Journal of biological engineering·2026
Same author

Restoring Mitochondrial Homeostasis: Therapeutic Strategies for Metabolic Dysfunction-Associated Fatty Liver Disease.

International journal of molecular sciences·2026
Same author

World Congress of Trauma and Emergency Leagues (WCTEL): looking for the future.

World journal of emergency surgery : WJES·2026
Same author

Oxidative phosphorylation and mitochondrial dynamics are regulated by Sestrin2 to maintain cellular function.

The FEBS journal·2026
Same author

Giant GIST: an uncommon cause of acute gastrointestinal bleeding.

BMJ case reports·2026
Same author

Predicting hypoparathyroidism after thyroidectomy: the value of indocyanine green fluorescence angiography.

Gland surgery·2025
Same journal

Pacemaker Status and 5-Year Mortality After TAVI: A Sex-Specific Analysis.

European journal of clinical investigation·2026
Same journal

Causal Effects of Time-Varying Treatments: The G-Formula.

European journal of clinical investigation·2026
Same journal

Improving Scientific Research: Renegotiated Principles of Science, Proposals, Failures, and Successes.

European journal of clinical investigation·2026
Same journal

Beta-Blockers After Myocardial Infarction With Preserved and Mildly Reduced Ejection Fraction: A Meta-Analysis With Trial Sequential Analysis.

European journal of clinical investigation·2026
Same journal

Prognostic Role of Serum Albumin Levels in Elderly Patients With Non-Valvular Atrial Fibrillation.

European journal of clinical investigation·2026
Same journal

Circulating Human Epididymis Protein 4 Predicts 10-Year Mortality and Major Adverse Cardiovascular Events in Patients With Peripheral Artery Disease.

European journal of clinical investigation·2026
See all related articles

Related Experiment Video

Updated: Mar 21, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.7K

Mitochondrial bioenergetics and posthepatectomy liver dysfunction.

Henrique Alexandrino1,2, Ana T Varela3,4, João Soeiro Teodoro3,4

  • 1Department of Surgery A, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

European Journal of Clinical Investigation
|May 4, 2016
PubMed
Summary
This summary is machine-generated.

Mitochondrial function declines with longer liver surgery clamping, impacting liver recovery. Assessing mitochondrial bioenergetics can predict and potentially treat post-hepatectomy liver failure.

Keywords:
Bioenergeticshepatectomyliver failuremitochondria

More Related Videos

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.4K
Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates
11:32

Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates

Published on: August 6, 2021

3.1K

Related Experiment Videos

Last Updated: Mar 21, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

9.7K
Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.4K
Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates
11:32

Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates

Published on: August 6, 2021

3.1K

Area of Science:

  • Hepatobiliary Surgery
  • Mitochondrial Physiology
  • Clinical Outcomes Research

Background:

  • Liver regeneration is energy-intensive, with mitochondrial function crucial for this process.
  • Clinical data on mitochondrial function during hepatectomy and its impact on patient outcomes are limited.
  • This study investigates mitochondrial changes during liver surgery and their clinical relevance.

Purpose of the Study:

  • To evaluate alterations in mitochondrial function during hepatectomy, particularly following hepatic pedicle clamping.
  • To correlate these mitochondrial changes with postoperative liver function and patient outcomes.
  • To assess the predictive value of mitochondrial bioenergetics for posthepatectomy complications.

Main Methods:

  • A prospective study involving 30 patients undergoing hepatectomy.
  • Intraoperative liver biopsies were analyzed for mitochondrial membrane potential, respiration, and adenosine triphosphate (ATP) content.
  • Correlations were drawn between clamping duration, postoperative liver function markers, and clinical outcomes.

Main Results:

  • Prolonged hepatic pedicle clamping correlated with impaired mitochondrial membrane potential and increased lag phase.
  • Worse mitochondrial function was associated with higher postoperative aminotransferases, international normalized ratio (INR), and bilirubin levels.
  • Decreased mitochondrial bioenergetics predicted liver-specific morbidity and posthepatectomy liver failure, with lag phase being a strong predictor.

Conclusions:

  • Mitochondrial function is intrinsically linked to hepatic pedicle clamping duration and clinical outcomes after hepatectomy.
  • Mitochondrial bioenergetic assessment holds potential for early diagnosis of postoperative liver dysfunction.
  • Targeting mitochondrial function may offer future therapeutic strategies for managing posthepatectomy complications.