[Epithelioid hemangioendothelioma of the liver]

Epitheloid hemangioendothelioma of the liver was found at autopsy of two women and one man (at the age of 67, 74 and 68). It occurred in multinodular form or as a huge tumours infiltration. In one case secondaries were noticed in a portal lymphnode and in the lung. Histology was characterized by epitheloid and elongated cells with irregular nuclei and sparse cytoplasmic vacuoles. A massive growth of tumour into sinusoid, central and portal veins resulted in a progressive liver atrophy or destruction. Differential diagnosis comprised epithelial tumours, especially cholangiocellular carcinoma, angiosarcoma and non-neoplastic processes (liver fibrosis and venoocclusive disease.