Cobalt-Catalyzed Enantioselective Vinylation of Activated Ketones and Imines
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Updated: Mar 21, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Yuan Huang1, Rui-Zhi Huang1, Yu Zhao1
1Department of Chemistry, National University of Singapore , 3 Science Drive 3, Republic of Singapore 117543.
Abstract:
We present here an unprecedented cobalt-catalyzed enantioselective vinylation of α-ketoesters, isatins, and imines to deliver a range of synthetically useful allylic alcohols and amines in high enantiopurity. This method employs commercially available and easy to handle catalysts and reagents and exhibits a high degree of practicality. The efficiency, selectivity, and operational simplicity of this catalytic system coupled with the substrate generality render this method a valuable tool in organic synthesis.
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