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Effect of cancer chemotherapy on dapsone N-acetylation in man
P A Philip1, P G Harper, H J Rogers
1Department of Clinical Pharmacology, United Medical, Guy's Hospital, London, U.K.
Cancer Chemotherapy and Pharmacology
|January 1, 1989
Abstract:
The effect of cancer chemotherapy on dapsone (DDS) N-acetylation was explored in 28 patients with various malignancies. There was a significant (P = 0.01) increase in plasma monoacetydapsone/dapsone (MADDS/DDS) ratios within 24 h of the start of chemotherapy (CT), indicating an acceleration of N-acetylation.