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Antimicrobial susceptibility patterns of Streptococcus pneumoniae.

R C Cooksey, R R Facklam, C Thornsberry

    Antimicrobial Agents and Chemotherapy
    |April 1, 1978
    PubMed
    Summary

    Antimicrobial susceptibility in Streptococcus pneumoniae has remained largely unchanged over a decade. However, a few strains show decreased susceptibility to penicillin, necessitating resistance screening for optimal treatment.

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    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Antimicrobial Resistance

    Background:

    • Streptococcus pneumoniae is a significant cause of bacterial infections.
    • Monitoring antimicrobial susceptibility is crucial for effective treatment.
    • Historical susceptibility data provides a baseline for comparison.

    Purpose of the Study:

    • To assess antimicrobial susceptibility patterns of Streptococcus pneumoniae.
    • To compare susceptibility between recent and historical isolates.
    • To identify emerging resistance, particularly to penicillin.

    Main Methods:

    • Disk-agar diffusion and agar dilution tests were used.
    • Susceptibility to 10 antimicrobial agents was evaluated.
    • Disk agar diffusion screened for penicillin resistance in additional isolates.

    Main Results:

    • Most isolates showed high susceptibility to tested drugs, except gentamicin.
    • One isolate exhibited reduced susceptibility to penicillin, ampicillin, and cephalothin.
    • Four recent isolates displayed elevated penicillin minimum inhibitory concentrations.

    Conclusions:

    • Antimicrobial susceptibility patterns for most drugs have been stable for over a decade.
    • Emerging penicillin resistance in Streptococcus pneumoniae is a concern.
    • Screening for penicillin resistance is clinically valuable, especially for blood and spinal fluid isolates.

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