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Related Experiment Videos

Microbial influences on urinary polyamine excretion.

H P Satink1, J Hessels, A W Kingma

  • 1Central Laboratory for Clinical Chemistry, University Hospital University of Groningen, The Netherlands.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 22, 1989
PubMed
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Urinary putrescine and cadaverine levels, including their monoacetylated forms, were analyzed. Urinary tract infections increase free putrescine, influenced by gastrointestinal and urinary tract microbial synthesis.

Area of Science:

  • Biochemistry
  • Microbiology
  • Urology

Background:

  • Polyamines like putrescine and cadaverine are crucial in biological processes.
  • Their levels in urine can reflect metabolic and microbial activity.
  • Understanding their origin and changes is vital for diagnostic interpretation.

Purpose of the Study:

  • To quantify diamines, polyamines, their monoacetylated conjugates, and catabolites in urine.
  • To investigate changes during gastrointestinal decontamination and in urinary tract infections (UTIs).
  • To assess the impact of in vitro incubation on these compounds.

Main Methods:

  • Urine samples from healthy individuals and UTI patients were analyzed.
  • Measurements were performed before and after gastrointestinal decontamination/therapy.

Related Experiment Videos

  • In vitro incubation experiments were conducted on urine samples.

    • Main Results:

    • Urinary total putrescine decreased during decontamination, mainly due to monoacetylated putrescine.
    • Free putrescine increased in UTI patients, decreasing post-therapy and increasing with incubation.
    • Total cadaverine decreased during decontamination and increased during recontamination; monoacetylated cadaverine contributed to these changes.

    Conclusions:

    • Monoacetylated putrescine and cadaverine originate partly from the gastrointestinal tract.
    • Urinary tract infections elevate free putrescine levels.
    • Microbial synthesis in the GI and urinary tracts impacts urinary putrescine interpretation for body cell turnover.