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[TAFRO syndrome and monoclonal gammapathy: Uncommon association!]
M Naifar1, M Messedi2, A Elleuch3
1Laboratoire de biochimie, CHU Habib Bourguiba, Sfax, Tunisie; Unité de recherche des bases moléculaires de la pathologie humaine 17ES12, faculté de médecine, Sfax, Tunisie.
Abstract:
Castleman's disease is a lymphoproliferative disorder characterized by angiofollicular lymph node hyperplasia. Recently, a new variant of multicentric Castleman's disease has been identified in Japan called TAFRO syndrome. It is characterized by a constellation of symptoms: thrombocytopenia, anasarca, reticulin fibrosis of the bone marrow, renal dysfunction and organomegaly (TAFRO). It is usually associated with polyclonal hyperimmunoglobulinemia. Here, we report the first and unique case of TAFRO syndrome with monoclonal gammapathy.
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