A self-tuning Smith predictor applied to the control of blood pressure: simulation studies

Significant time-delays occur in the response of blood pressure to drug therapy. The classical Smith predictor algorithm used to eliminate such delays is extended here to the principle of self-tuning under mis-match conditions. Two delay-free controller algorithms are investigated, being a self-tuning pole-placement and a self-tuning PID structure. Extensive simulation studies using the well-known Slate model have demonstrated the good transient performance obtained with this self-tuning Smith principle in various combinations, and under realistic variability of patient dynamics.