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Paediatric reference ranges for faecal calprotectin: a UK study.

Fiona Davidson¹, Robert J Lock²

¹1 Clinical Biochemistry, North Bristol NHS Trust, Bristol, UK.

Annals of Clinical Biochemistry

|May 4, 2016

Summary

This summary is machine-generated.

Faecal calprotectin levels vary by age in children and adults. Younger children (1-3.9 years) show higher levels than adults, while older children (4-17.9 years) have similar levels to adults. Establishing age-specific reference ranges is crucial.

Keywords:

Calprotectin inflammatory bowel disease paediatric reference ranges

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Published on: June 24, 2020

Area of Science:

Gastroenterology
Clinical Chemistry
Pediatrics

Background:

Faecal calprotectin is a key non-invasive biomarker for diagnosing and monitoring inflammatory bowel disease (IBD).
Established reference ranges for adults exist, but pediatric ranges require further investigation.
Understanding age-specific faecal calprotectin levels is vital for accurate pediatric IBD assessment.

Purpose of the Study:

To establish age-specific reference ranges for faecal calprotectin in a local population.
To compare faecal calprotectin levels across different pediatric and adult age groups.

Main Methods:

Retrospective analysis of faecal calprotectin results from 2011-2014.
Data grouped by age: 1-3.9 years, 4-17.9 years, and 18+ years.
Probability plots and Mann-Whitney tests used to determine upper limits of normal and statistical significance.

Main Results:

Upper limits of normal (µg/g): 77 (1-3.9 yrs), 62 (4-17.9 yrs), 61 (18+ yrs).
Significant differences in median faecal calprotectin between 1-3.9 years and older groups (P < 0.0013).
No significant difference found between older children (4-17.9 yrs) and adults (P = 0.4206).

Conclusions:

Faecal calprotectin concentrations demonstrate age-dependent variation in the local population.
Younger children exhibit higher faecal calprotectin than adults; older children's levels are comparable to adults.
The established upper limit of normal for 1-3.9 year olds is lower than reported in other studies.