Related Experiment Video

Updated: Mar 21, 2026

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
09:10

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Published on: January 7, 2022

2.8K

[Irumamicin Produced by Streptomyces roseoflavus INA-1278]

O A Lapchinskaya, G S Katrukha, L P Terekhova

    Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
    |May 5, 2016
    PubMed

    Insights

    A new strain, Streptomyces roseoflavus INA-1278, produces irumamicin. This novel irumamicin exhibits distinct antifungal activity compared to that from Streptomyces subflavus.

    Area of Science:

    • Microbiology
    • Natural Products Chemistry
    • Antimicrobial Research

    Background:

    • Streptomyces species are prolific producers of bioactive secondary metabolites.
    • Irumamicin is an antifungal agent previously isolated from Streptomyces subflavus.
    • Characterizing novel natural products is crucial for discovering new therapeutic agents.

    Purpose of the Study:

    • To identify and characterize a new producer of irumamicin.
    • To investigate the antifungal properties of the newly produced irumamicin.
    • To compare the antifungal activity of the novel irumamicin with the known compound.

    Main Methods:

    • Isolation and identification of the bacterial strain Streptomyces roseoflavus INA-1278.
    • Fermentation and extraction of the secondary metabolite.
    • Antifungal activity assays against relevant microbial targets.
    • Comparative analysis of antifungal profiles.

    Main Results:

    • Streptomyces roseoflavus INA-1278 was identified as a novel irumamicin-producing strain.
    • The irumamicin produced by INA-1278 (Irumamicin 1278) demonstrated antifungal activity.
    • Significant differences in antifungal activity were observed between Irumamicin 1278 and the irumamicin from Streptomyces subflavus.

    Conclusions:

    • Streptomyces roseoflavus INA-1278 represents a new source for irumamicin production.
    • The distinct antifungal profile of Irumamicin 1278 warrants further investigation for potential applications.
    • This discovery expands the known diversity of irumamicin-producing microorganisms and their bioactive compounds.

    More Related Videos

    Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids11:56

    Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

    Published on: May 4, 2018

    13.1K
    From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü602809:08

    From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

    Published on: January 13, 2017

    17.9K

    Related Concept Videos

    Production of Antibiotics01:27

    Production of Antibiotics

    Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...
    6
    Production of Pharmaceuticals01:30

    Production of Pharmaceuticals

    Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under...
    22
    Inhibitors of Bacterial Protein Synthesis01:25

    Inhibitors of Bacterial Protein Synthesis

    Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
    17