Related Experiment Video
Updated: Mar 21, 2026

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
Published on: July 17, 2021
[Analysis and Discussion on Calculating Likelihood Ratio of DNA Mixture]
Objective:
To analyze and discuss four methods of calculating likelihood ratio of DNA mixture.
Methods:
In the case with CNAS-T0757 proficiency testing in 2013, the likelihood ratios were calculated and compared among four methods, including unrestricted combinatorial method, Clayton's method, p2 principle method, and recommendations from ISFG.
Results:
The likelihood ratios were maximum by Clayton's method and recommendations from ISFO, followed by result of the unrestricted combinational method. The minimum likelihood ratio was obtained by p2 principle.
Conclusion:
The unrestricted combinational method could give fUrthest consideration to both information preservation and appraiser protection.
Related Concept Videos
Probability Laws
Chi-square Analysis
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
Hardy-Weinberg Principle
DNA as a Genetic Template
Homologous Recombination
Law of Segregation

