Peripheral nerve regeneration in quail-chick spinal cord chimeras treated with oral ciclosporin

Regeneration of chimeric wing nerves in 2 quail-chick spinal cord chimeras is reported. The large DNA-containing quail nucleolar marker could not be distinguished in flattened cells, and in particular, in perineurial cell nuclei of chimeric nerves. With oral ciclosporin treatment, rejection of graft-derived nervous system tissues was acute and florid in one chimera, but followed a chronic, remitting course in the other.