Related Experiment Video
Updated: Mar 21, 2026
07:25
Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
6.3K
Malignancy associated SIADH: Characterization and clinical implications.
H Goldvaser1,2, B Rozen-Zvi3,2, R Yerushalmi1,2
1a Institute of Oncology , Davidoff Center, Rabin Medical Center , Petach Tikva , Isarel.
Acta Oncologica (Stockholm, Sweden)
|May 5, 2016
Summary
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is linked to most cancers. Malignancy-associated SIADH significantly worsens patient outcomes, but short-term sodium correction may improve survival.
Area of Science:
- Oncology
- Endocrinology
- Nephrology
Background:
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common endocrine disorder.
- SIADH can be associated with various conditions, including malignancies.
- Understanding the specific etiologies of SIADH in cancer patients is crucial for prognosis and management.
Purpose of the Study:
- To determine the distribution of SIADH etiologies in hospitalized patients with active malignancies.
- To characterize SIADH in cancer patients based on different underlying causes.
- To investigate the association between malignancy-associated SIADH and patient outcomes.
Main Methods:
- A retrospective study was conducted at a single center, including patients with active malignancies and SIADH.
- Medical records of 204 patients diagnosed between January 2007 and January 2013 were reviewed.
- Clinical data were extracted and analyzed to identify SIADH etiologies and patient characteristics.
Main Results:
- Malignancy-associated SIADH was observed in 73% of patients; other etiologies accounted for 27%.
- Patients with breast cancer without lung or brain metastasis were less likely to have malignancy-associated SIADH.
- Malignancy-associated SIADH correlated with lower serum sodium levels and significantly shorter median survival (58 vs. 910 days).
Conclusions:
- SIADH is associated with a wide range of malignancy types.
- For breast cancer patients with SIADH and no apparent cause, imaging for metastatic disease is recommended.
- Malignancy-associated SIADH portends a poorer prognosis, with short-term sodium correction indicating better survival prospects.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
874
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
874
01:24Chronic Kidney Disease II: Clinical Manifestations
909
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
909
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
709
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
709
01:26Heart Failure III: Clinical Manifestations
821
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
821
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
643
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
643
01:30Cardiomyopathy II: Dilated Cardiomyopathy
733
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
733