Related Experiment Video
Updated: Mar 21, 2026
09:31
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
9.3K
Optical Coherence Tomography of the Aging Kidney
Peter M Andrews1, Hsing-Wen Wang, Hengchang Guo
1From the Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington DC 20007, USA.
Summary
Optical coherence tomography (OCT) can detect age-related kidney damage. This noninvasive imaging technique identifies histopathologic changes like fibrosis and tubular atrophy in aging kidneys.
Area of Science:
- Nephrology
- Medical Imaging
- Gerontology
Background:
- Aging kidneys show functional decline and histopathologic changes, posing risks for renal transplantation.
- Individual variations in kidney aging necessitate reliable assessment methods.
- Optical coherence tomography (OCT) is a noninvasive imaging technique emerging for kidney evaluation.
Purpose of the Study:
- To assess OCT's capability in detecting age-associated histopathologic changes in the kidney.
- To correlate OCT findings with renal function and traditional histopathology in aging kidneys.
Main Methods:
- The study utilized Munich-Wistar rats to evaluate OCT's efficacy in identifying age-related kidney alterations.
- OCT observations were compared with measurements of renal function and light microscopic analysis.
Main Results:
- At 10-12 months, OCT detected tubular necrosis/atrophy, interstitial fibrosis, tubular dilation, and glomerulosclerosis coinciding with proteinuria.
- By 16-18 months, with declining renal function (increased creatinine), OCT revealed more pronounced interstitial fibrosis, tubular atrophy, and glomerular sclerosis.
Conclusions:
- OCT demonstrates potential for detecting the histopathology of progressive nephropathy linked to kidney aging.
- This noninvasive imaging method may aid in assessing the suitability of aging kidneys for transplantation.
More Related Videos
Related Concept Videos
01:28Imaging Studies I: Kidney, Ureter, and Bladder Studies
605
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
605
01:20Renal Corpuscle
8.4K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
8.4K
01:45Kidney Structure
76.4K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
76.4K
01:21External Anatomy of the Kidney
4.6K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
4.6K
01:12Internal Anatomy of the Kidney
8.3K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
8.3K
01:27Imaging Studies III: Computed Tomography
604
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
604