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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
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Single- versus multiple-tablet HIV regimens: adherence and hospitalization risks.

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  • 1South Carolina College of Pharmacy, University of South Carolina, 715 Sumter St (CLS 314b), Columbia, SC 29208-0001.

The American Journal of Managed Care
|May 5, 2016
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Single-tablet regimens (STRs) for human immunodeficiency virus (HIV)/AIDS improve medication adherence, reduce hospitalizations, and increase undetectable viral loads compared to multiple-tablet regimens (MTRs) in VHA patients.

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Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Public Health

Background:

  • Antiretroviral therapy (ART) is crucial for managing human immunodeficiency virus (HIV)/AIDS.
  • Single-tablet regimens (STRs) offer a simplified treatment option compared to multiple-tablet regimens (MTRs).
  • Evaluating the comparative effectiveness of STRs versus MTRs is essential for optimizing HIV care.

Purpose of the Study:

  • To assess the impact of STRs versus MTRs on key outcomes in HIV/AIDS patients.
  • To compare hospitalization rates, treatment adherence, and viral load suppression between STR and MTR users.
  • To analyze data from electronic health records within the Veterans Healthcare Administration (VHA).

Main Methods:

  • Retrospective cohort study design.
  • Inclusion of VHA patients receiving ART between January 1, 2006, and July 30, 2012.
  • Analysis of adherence (≥95% medication possession ratio), hospitalization, and undetectable viral load using Cox-proportional hazard and logistic models.

Main Results:

  • The STR cohort demonstrated significantly higher adherence rates (OR, 1.98; P < .001).
  • STR use was associated with a 31% lower hazard of hospitalization (HR, 0.69; P < .001).
  • Patients on STRs had 21% higher odds of achieving an undetectable viral load (OR, 1.21; P < .001).

Conclusions:

  • STRs are associated with improved adherence in HIV/AIDS patients.
  • STRs lead to decreased hospitalizations compared to MTRs.
  • STRs contribute to a higher proportion of patients achieving undetectable viral loads.