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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
[Pregnancy in systemic autoimmune diseases: Myths, certainties and doubts]
Álvaro Danza1, Guillermo Ruiz-Irastorza2, Munther Khamashta3
1Unidad Docente Asistencial en Enfermedades Autoinmunes Sistémicas y Reumatológicas, Clínica Médica, Hospital Pasteur, Departamento de Medicina, Facultad de Medicina, Universidad de la República, Administración de Servicios de Salud del Estado (ASSE), Montevideo, Uruguay; Unidad de Investigación de Enfermedades Autoinmunes, Servicio de Medicina Interna, BioCruces Health Research Institute, Hospital Universitario Cruces, Universidad del País Vasco (UPV)/Euskal Herriko Unibertsitatea (EHU), Barakaldo, Vizcaya, España.
Abstract:
Systemic autoimmune diseases especially affect young women during childbearing age. The aim of this review is to update systemic lupus erythematosus, antiphospholipid syndrome and systemic sclerosis management during pregnancy. These diseases present variable maternal and fetal risks. Studies show that an appropriate disease control and a reasonable remission period prior to pregnancy are associated with satisfactory obstetric outcomes. Antiphospholipid autoantibodies profile, anti-Ro/anti-La antibodies, pulmonary pressure and activity evaluation are crucial to assess the pregnancy risk. Monitoring requires a multidisciplinary team, serial analytic controls and Doppler ultrasound of maternal and fetal circulation. Evaluation of the activity of the disease is essential.
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