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Calcium channel modulators: effects on gastric function.

G B Glavin1

  • 1Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

European Journal of Pharmacology
|February 7, 1989
PubMed
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Calcium channel blockers like nitrendipine, verapamil, and diltiazem show potential in reducing gastric lesions, particularly stress-induced ones. Their efficacy varies, suggesting a possible clinical role in managing gastric conditions.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Physiology

Background:

  • Calcium ions play a crucial role in stimulus-secretion coupling within the gastrointestinal tract.
  • Understanding the role of calcium channels in gastric function is essential for developing new therapeutic strategies.

Purpose of the Study:

  • To investigate the effects of specific calcium channel blockers (nitrendipine, verapamil, diltiazem) and an agonist (CGP 28392) on gastric function.
  • To evaluate their efficacy in different gastric lesion models and their impact on gastric acid secretion.

Main Methods:

  • Administration of dihydropyridine (nitrendipine), phenylalkylamine (verapamil), and benzothiazepine (diltiazem) calcium channel blockers, and a calcium channel agonist (CGP 28392).
  • Testing in models of stress-induced and ethanol-induced gastric lesions.

Related Experiment Videos

  • Assessment of reversibility of effects with indomethacin, sodium meclofenamate, and N-ethylmaleimide.
  • Measurement of basal gastric acid output.

    • Main Results:

    • Nitrendipine significantly reduced stress-induced gastric lesions and basal acid output, but was less effective against ethanol-induced lesions.
    • Verapamil and diltiazem reduced stress lesions (reversibly with NSAIDs) and basal acid secretion, but exacerbated ethanol-induced ulcers.
    • CGP 28392 showed modest gastroprotection against stress, reduced ethanol lesions, and slightly decreased basal acid secretion.

    Conclusions:

    • Calcium channel blockade demonstrates potential therapeutic benefits for stress-induced gastric conditions.
    • The differential effects highlight the complexity of calcium channel modulation in gastric physiology.
    • Further research may elucidate a clinical role for gastric calcium channel blockade in treating specific gastrointestinal disorders.