Related Experiment Video

Updated: Mar 21, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.9K

Sacroiliitis and Polyarteritis Nodosa in a Patient with Familial Mediterranean Fever

Yunus Ugan1, Atalay Doğru1, Hüseyin Şencan2

  • 1Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Suleyman Demirel University, 32260 Isparta, Turkey.

Case Reports in Medicine
|May 5, 2016
PubMed

Insights

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by MEFV gene mutations. This case highlights a rare FMF presentation with both sacroiliitis and polyarteritis nodosa (PAN).

Area of Science:

  • Genetics
  • Rheumatology
  • Immunology

Background:

  • Familial Mediterranean fever (FMF) is an autoinflammatory disorder with autosomal recessive inheritance.
  • It is characterized by recurrent fever and serositis, caused by mutations in the MEFV gene.
  • While over 310 MEFV variants exist, clinical diagnosis remains standard.

Purpose of the Study:

  • To report a rare clinical presentation of FMF.
  • To discuss the association of FMF with sacroiliitis and polyarteritis nodosa (PAN).

Main Methods:

  • Case report.
  • Clinical diagnosis of FMF.
  • Review of literature on FMF, sacroiliitis, and vasculitis.

Main Results:

  • The case presented a rare co-occurrence of FMF, sacroiliitis, and PAN.
  • Polyarteritis nodosa (PAN) and Henoch-Schonlein purpura are the most common vasculitides associated with FMF.

Conclusions:

  • FMF can present with rare complications like sacroiliitis and PAN.
  • Awareness of these associations is crucial for comprehensive patient management.

Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
433
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
797
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
609
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
507
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.5K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
958