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Current practices and guidelines for clinical next-generation sequencing oncology testing
1Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Next-generation sequencing (NGS) offers extensive genomic data for cancer care. This review covers NGS applications and guidelines for interpreting DNA variants in solid tumors and hematological malignancies.
Area of Science:
- Oncology
- Molecular Pathology
- Genomics
Background:
- Next-generation sequencing (NGS) is revolutionizing molecular pathology.
- It significantly expands the genomic information available for cancer diagnosis and treatment.
Purpose of the Study:
- To review the current applications of NGS in oncology.
- To focus on guidelines for assessing the technical validity and clinical utility of DNA variants.
Main Methods:
- Literature review of NGS applications in solid tumors and hematological malignancies.
- Analysis of current practices and guidelines for variant assessment.
Main Results:
- NGS provides comprehensive genomic insights for oncologists.
- Established guidelines are crucial for evaluating DNA variants identified in clinical oncology testing.
Conclusions:
- NGS is a powerful tool in modern oncology, enhancing patient care.
- Rigorous assessment of technical validity and clinical utility ensures the effective use of NGS-generated genomic data.
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