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Changing paradigm of cancer therapy: precision medicine by next-generation sequencing

Yuan Xue1, William R Wilcox2

  • 1Fulgent Diagnostics, Temple City, CA 91780, USA.

Cancer Biology & Medicine
|May 5, 2016
PubMed

Insights

Precision medicine uses next-generation sequencing (NGS) to tailor cancer therapy. NGS enhances treatment for solid tumors by improving molecular diagnosis and monitoring patient response.

Area of Science:

  • Oncology
  • Genomics
  • Precision Medicine

Background:

  • Cancer therapy faces challenges with variable treatment response and drug resistance.
  • Solid tumors exhibit significant cellular and developmental diversity, complicating treatment.
  • Precision medicine seeks to optimize drug selection, dosage, and timing for individual patients.

Purpose of the Study:

  • To provide an overview of how next-generation sequencing (NGS) facilitates precision medicine in cancer therapy.
  • To highlight the impact of NGS on solid tumor treatment paradigms.
  • To discuss the role of NGS in technical advancements, molecular diagnosis, response monitoring, and clinical trials.

Main Methods:

  • Review of next-generation sequencing (NGS) applications in oncology.
  • Analysis of NGS's role in molecular diagnosis and treatment response monitoring.
  • Exploration of NGS's contribution to clinical trials for solid tumors.

Main Results:

  • NGS enables comprehensive analysis of genetic alterations in complex cancers.
  • NGS facilitates personalized treatment strategies for solid tumors.
  • NGS improves molecular diagnosis, response monitoring, and clinical trial design.

Conclusions:

  • Next-generation sequencing is a key technology driving precision medicine in oncology.
  • NGS transforms cancer therapy, particularly for heterogeneous solid tumors.
  • The integration of NGS enhances the effectiveness and personalization of cancer treatments.
Keywords:
Precision medicinecancer therapynext-generation sequencingsolid tumor

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