Related Experiment Videos
Recombinant H-chain ferritins: effects of changes in the 3-fold channels
A Treffry1, P M Harrison, A Luzzago
1Department of Molecular Biology and Biotechnology, The University, Sheffield, England.
FEBS Letters
|April 24, 1989
Abstract:
Human H-chain ferritins bearing sequence changes in the 3-fold channels have been expressed in E. coli to investigate the role of these channels in iron-storage processes. The proteins assemble into shells resembling those of native ferritins. Iron uptake measurements indicate that residues in the 3-fold channels are involved neither in initial Fe(II)-oxidation nor in iron-core nucleation.