Related Experiment Video

Updated: Mar 21, 2026

Breath Collection from Children for Disease Biomarker Discovery
06:09

Breath Collection from Children for Disease Biomarker Discovery

Published on: February 14, 2019

7.4K

Cord Blood Soluble CD14 Predicts Wheeze and Prolonged Cough in Young Children: The PATCH Study

Kuan-Wen Su1, Yu-Ling Tu, Chih-Yung Chiu

  • 1Department of Pediatrics, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan (ROC).

International Archives of Allergy and Immunology
|May 5, 2016
PubMed

Insights

Soluble cluster of differentiation 14 (sCD14) in cord blood can predict wheezing and prolonged cough in infants. Higher sCD14 levels indicate an increased risk of developing these common respiratory issues by one year of age.

Area of Science:

  • Pediatric Allergy and Immunology
  • Biomarker Discovery
  • Neonatal Health

Background:

  • Soluble cluster of differentiation 14 (sCD14) is implicated in atopic symptom development, but prior research is inconsistent.
  • The role of sCD14 as an early indicator of allergic conditions in infants requires further investigation.

Purpose of the Study:

  • To assess the utility of cord blood sCD14 as a predictive biomarker for identifying allergy and respiratory symptoms in early childhood.
  • To determine if sCD14 levels at birth can forecast the development of wheeze and prolonged cough by age one.

Main Methods:

  • Enrollment of infants (0-1 year) from the Prediction of Allergies in Taiwanese Children (PATCH) birth cohort.
  • Measurement of sCD14 concentrations in cord blood samples.
  • Periodic pediatrician evaluations and questionnaire-based symptom tracking until 1 year of age.

Main Results:

  • A cohort of 206 infants was analyzed.
  • Cord blood sCD14 showed a positive association with wheeze and prolonged cough.
  • Multivariate analysis identified cord blood sCD14 as the sole independent predictor for wheeze and prolonged cough, with increased levels correlating to higher risk.

Conclusions:

  • Cord blood sCD14 emerges as a potential predictive biomarker for infant wheeze and prolonged cough.
  • Elevated sCD14 levels at birth may signify an increased likelihood of developing these respiratory conditions within the first year of life.
Abstract

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.1K
Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

2.1K

Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.3K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.6K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.4K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
4.7K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.8K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.2K