New Aspects in the Formulation of Drugs Based on Three Case Studies

Area of Science:

• Pharmaceutical Technology
• Materials Science
• Biomedical Engineering

Background:

• Optimizing pharmaceutical dosage forms for controlled drug delivery and cost-efficiency is crucial.
• Current formulation technologies face challenges in achieving both efficacy and economic viability.

Purpose of the Study:

• To present three innovative formulation technologies: in situ coating, freeze casting, and protein-based biocomposites.
• To demonstrate how these methods improve drug delivery systems (DDS) in terms of control and cost-efficiency.
• To highlight advancements in tailor-made drug delivery.

Main Methods:

• In situ coating: Applied to enhance economic efficiency and enable tailorable drug release rates.
• Freeze casting: Utilized to control the surface area and pore structure of DDS for accelerated dissolution.
• Protein-based biocomposites: Developed for incorporating crystalline active pharmaceutical ingredients (API) into a protein matrix in a single step.

Main Results:

• In situ coating offers economic benefits by reducing process steps and allows for precise control over drug release.
• Freeze casting provides tunable surface area and pore characteristics, enhancing drug dissolution.
• Protein-based biocomposites offer biocompatibility, biodegradability, and a novel method for API incorporation.

Conclusions:

• These three techniques represent significant progress in developing functional, cost-effective, and value-added drug delivery systems.
• The presented methods contribute to the creation of personalized and advanced pharmaceutical formulations.
• Further development in formulation technologies is driven by innovations in controlled drug release and material science.