Related Experiment Video
Updated: Mar 21, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones
Valentina Onnis1, Monica Demurtas2, Alessandro Deplano3
1Dipartimento di Scienze della Vita e dell'Ambiente, Sezione di Scienze Farmaceutiche, Farmacologiche e Nutraceutiche, Università degli Studi di Cagliari, Via Ospedale 72, Cagliari I-09124, Italy. vonnis@unica.it.
Abstract:
The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N'-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210), human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human pancreas carcinoma cells (Mia Paca-2). A preliminary structure-activity relationship could be defined. Some of the compounds possess encouraging and consistent antiproliferative activity, having IC50 values in the low micromolar range.
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Antihypertensive Drugs: Thiazide-Class Diuretics
Diazonium Group Substitution: –OH and –H
Anthelminthic Agents
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions

