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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Soluble Epoxide Hydrolase as a Potential Key Factor for Human Prenatal Development.

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    Soluble epoxide hydrolase (sEH) is present throughout human prenatal development. Its expression pattern suggests a role in fetal organ development, with potential risks from environmental exposures.

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    Area of Science:

    • Developmental biology
    • Biochemistry
    • Pharmacology

    Background:

    • Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), which are crucial for organism development.
    • EETs are implicated as potential morphogens, but their expression during human development is poorly understood.

    Purpose of the Study:

    • To investigate the spatio-temporal expression of sEH in human embryonic and fetal organs during intrauterine development (IUD).
    • To explore the potential role of sEH and EETs in human organogenesis.

    Main Methods:

    • Two-step immunohistochemistry was used to detect sEH expression.
    • Human embryonic/fetal intestines, liver, and kidney samples from the 6th to 20th week of IUD were analyzed.

    Main Results:

    • sEH was consistently expressed throughout the entire period of human prenatal development examined (6-20 weeks IUD).
    • sEH expression levels remained relatively stable during this developmental window.
    • Co-localization of sEH with CYP epoxygenases in the intestinal epithelium and kidney nephrogenic zone suggests EET involvement in cell proliferation and differentiation.

    Conclusions:

    • sEH plays a role throughout human intrauterine development, potentially influencing organogenesis.
    • Disruptions to the spatio-temporal expression of CYP epoxygenases or sEH by xenobiotics could adversely affect fetal development.