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[Recurrence and morphologic resistance phenomena of PUVA-treated lichen ruber planus cutaneous]
Dermatologische Monatschrift
|January 1, 1989
Abstract:
145 patients with lichen planus cutaneous were treated with PUVA. In a follow-up period of 1 to 4 years 6 of the patients (4.1%) showed a generalised recurrence and 32 patients (22%) a local recurrence. For the first time 3 morphological PUVA-resistance phenomena were observed. Recurrence- and resistance correlation are discussed.
Insights
This study on 145 patients found that 22% experienced local recurrence and 4.1% generalized recurrence of cutaneous lichen planus after PUVA therapy. It also identified three novel PUVA-resistance phenomena.
Area of Science:
- Dermatology
- Phototherapy
- Immunology
Context:
- Lichen planus cutaneous (LPC) is a chronic inflammatory condition.
- PUVA (psoralen plus ultraviolet A) therapy is a common treatment for LPC.
- Understanding treatment efficacy and recurrence patterns is crucial for patient management.
Purpose:
- To evaluate the long-term recurrence rates of cutaneous lichen planus following PUVA treatment.
- To identify and describe novel morphological phenomena associated with PUVA resistance.
- To explore the correlation between recurrence and resistance in PUVA-treated LPC patients.
Summary:
- A cohort of 145 patients with cutaneous lichen planus received PUVA therapy.
- Over a 1-4 year follow-up, 22% experienced local recurrence and 4.1% generalized recurrence.
- Three new morphological patterns of PUVA resistance were observed and are discussed in relation to recurrence.
Impact:
- Provides critical data on the long-term outcomes of PUVA therapy for cutaneous lichen planus.
- Introduces novel observations of PUVA resistance, potentially guiding future treatment strategies.
- Highlights the importance of monitoring for both recurrence and resistance in clinical practice.