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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time
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Optical imaging probes in oncology.

Cristina Martelli1,2, Alessia Lo Dico1,3, Cecilia Diceglie1,2,4

  • 1Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

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|May 5, 2016
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Summary

Optical imaging offers a non-invasive method for early cancer detection and characterization in preclinical studies. This review details available optical imaging procedures and probes for assessing tumor features in mouse models.

Keywords:
biomarkerscancerfluorescent probesmolecular processestumor cell features

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Area of Science:

  • Oncology
  • Biomedical Imaging

Background:

  • Cancer is a complex disease requiring early detection for improved patient outcomes.
  • Non-invasive molecular imaging aids in the early identification of tumor biomarkers.
  • Current clinical imaging relies on CT, nuclear imaging, and MRI, while preclinical studies also utilize optical imaging.

Purpose of the Study:

  • To provide a comprehensive overview of optical imaging procedures for non-invasive tumor assessment in preclinical oncological murine models.
  • To discuss the characteristics of both commercially available and newly developed optical imaging probes.

Main Methods:

  • Review of existing literature on optical imaging techniques in cancer research.
  • Analysis of fluorescent and luminescent reporter genes and probes used in small animal models.
  • Discussion of commercially available and novel optical imaging probes.

Main Results:

  • Optical imaging utilizes luminescent or fluorescent reporter genes or probes for fluorescence and luminescence imaging.
  • Most optical probes are currently used in animal models, with clinical applications under evaluation.
  • A wide range of probes are commercially available, with continuous development of new probes.

Conclusions:

  • Optical imaging is a significant application in preclinical oncology, offering ease of use and valuable insights into tumor features.
  • The review highlights the importance and potential of optical imaging for non-invasive tumor assessment in murine models.