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Related Concept Videos

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption
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Echo intensity independently predicts functionality in sedentary older men.

Pedro Lopez1, Eurico Nestor Wilhelm2, Anderson Rech1

  • 1Exercise Research Laboratory (LAPEX), Federal University of Rio Grande do Sul (UFRGS), Felizardo Street, 750 - Jardim Botânico, CEP: 90690-200, Porto Alegre, RS, Brazil.

Muscle & Nerve
|May 5, 2016
PubMed
Summary
This summary is machine-generated.

Quadriceps echo intensity (QEI) best predicts functional performance in older men. This finding suggests QEI can screen for muscle impairment impacting mobility in this demographic.

Keywords:
agingfunctionalitymuscle qualitymuscular performanceultrasonography

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Area of Science:

  • Gerontology
  • Muscle Physiology
  • Biomedical Engineering

Background:

  • Maintaining muscle function is crucial for older adults' independence.
  • Sedentary lifestyles in older men can lead to decreased muscle function and performance.
  • Identifying reliable indicators of muscle impairment is essential for targeted interventions.

Purpose of the Study:

  • To investigate associations between quadriceps muscle functionality metrics and functional performance in nonactive older men.
  • To identify predictors of functional performance in this population.
  • To evaluate quadriceps echo intensity (QEI) as a potential screening tool.

Main Methods:

  • Assessed 50 healthy, sedentary older men (mean age 66 years).
  • Measured quadriceps functional parameters: QEI, rate of torque development (RTD), and 30-second sit-to-stand test (30SS).
  • Calculated RTD/QEI ratios and performed multiple stepwise linear regression analysis.

Main Results:

  • 30SS performance correlated with RTD, muscle thickness, and various RTD/QEI ratios.
  • Quadriceps echo intensity (QEI) emerged as the strongest single predictor of functional performance.
  • QEI explained approximately 30% of the variance in 30SS performance.

Conclusions:

  • QEI is a significant contributor to the functionality of nonactive older men.
  • QEI may serve as an effective tool for screening muscle impairment.
  • Early screening can help identify individuals at risk for decreased functional performance.