Related Experiment Video

Updated: Mar 21, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.8K

Formula and breast feeding in infant food allergy: A population-based study

Alice J Goldsmith1,2, Jennifer J Koplin2,3, Adrian J Lowe2,4

  • 1School of Medicine, Sydney, University of Notre Dame, Sydney, New South Wales, Australia.

Journal of Paediatrics and Child Health
|May 5, 2016
PubMed

Insights

Exclusive breastfeeding duration and partially hydrolyzed formula use do not affect infant food allergy risk. This large study found no link between these feeding practices and allergy development at one year of age.

Area of Science:

  • Pediatric Allergy and Immunology
  • Nutritional Epidemiology
  • Public Health Nutrition

Background:

  • Infant feeding practices are critical for immune development.
  • The role of breastfeeding and specialized formulas in preventing food allergies remains debated.
  • Understanding these associations is crucial for evidence-based infant feeding guidelines.

Purpose of the Study:

  • To investigate the association between exclusive breastfeeding duration and infant food allergy.
  • To determine if partially hydrolyzed formula use modifies the risk of developing food allergy.
  • To inform public health recommendations on infant feeding for allergy prevention.

Main Methods:

  • Observational, population-based study of 5276 infants in Melbourne, Australia.
  • Data collected on infant feeding practices and confounders.
  • Food allergy status determined by skin prick testing and oral food challenges.

Main Results:

  • No association found between exclusive breastfeeding duration and food allergy at 1 year.
  • Partially hydrolyzed formula use did not reduce food allergy risk compared to cow's milk formula.
  • 11.3% of infants studied were diagnosed with food allergy.

Conclusions:

  • Exclusive breastfeeding duration and partially hydrolyzed formula are not associated with food allergy at one year.
  • Findings do not support the use of partially hydrolyzed formula for food allergy prevention.
  • Results have implications for population-based infant feeding guidelines.
Abstract

Keywords:
allergy preventionbreastfeedingfood allergyinfant feedinginfant formula

More Related Videos

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets08:12

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Published on: September 6, 2019

7.7K
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

17.0K

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
713
Allergic Reactions02:06

Allergic Reactions

Overview
33.4K
Bioavailability Study Design: Absolute Versus Relative Bioavailability01:27

Bioavailability Study Design: Absolute Versus Relative Bioavailability

Bioavailability is a crucial pharmacokinetic parameter that quantifies the proportion of an administered drug that reaches the systemic circulation and is available for therapeutic action. Regulatory agencies mandate the assessment of bioavailability, typically measured as the area under the drug plasma concentration-versus-time curve (AUC), to ensure the efficacy and safety of pharmaceutical products. These evaluations are categorized as absolute and relative bioavailability studies.Absolute...
517
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
142
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K