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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an
Ignacio Colomer1, Christopher J Empson, Philip Craven
1School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK. s.p.marsden@leeds.ac.uk a.s.nelson@leeds.ac.uk.
Chemical Communications (Cambridge, England)
|May 6, 2016
Abstract:
Complementary cyclisation reactions of hex-2-ene-1,6-diamine derivatives were exploited in the synthesis of alternative molecular scaffolds. The value of the synthetic approach was analysed using LLAMA, an open-access computational tool for assessing the lead-likeness and novelty of molecular scaffolds.
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