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Updated: Mar 21, 2026

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Complications following inguinal and ilioinguinal lymphadenectomies: a meta-analysis
Martin Söderman1, Jørn B Thomsen1, Jens A Sørensen1
1a Department of Plastic Surgery , Odense University Hospital , Odense , Denmark.
Background:
Inguinal lymphadenectomy is essential for regional staging of malignant melanoma in the lower part of the body. The procedure is associated with a wide range of complication rates. The objective of this study was to systematically review the literature for papers describing complication rates following inguinal (ID) and ilioinguinal (I-ID) lymphadenectomies, and estimate the actual complication rates in patients with malignant melanoma.
Methods:
The PubMed and EMBASE databases were searched for studies reporting complications following ID and I-ID for malignant melanomas.
Results:
A total of 416 records were identified, of which 20 were deemed eligible for this study. The complication rates (with 95% confidence intervals) were found to be as follows: overall complications = 52% (44-60%); lymphorrea = 29% (0-71%); seroma = 23% (18-29%); infection = 21% (15-27%); wound breakdown =14% (8-21%); skin edge necrosis = 10% (6-15%); haematoma = 3% (1-5%); and lymphoedema = 33% (25-42%).
Conclusion:
Complication rates following ID and I-ID remain high, despite the many efforts to reduce these, with lymphorrea, seromas, and infections being the most prevalent complications.
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