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Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
Published on: November 3, 2018
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Bone marrow hyperplasia detected by gated blood pool imaging
Tarun Jain1, Alka Khadwal2, Ashwani Sood3
1Department of Nuclear Medicine, Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Summary
Multigated acquisition (MUGA) scans using Technetium-99m labeled red blood cells can reveal bone marrow hyperplasia. This study highlights abnormal tracer uptake in the rib cage of a thalassemia patient, showing scintigraphic evidence of hyperplasia.
Area of Science:
- Nuclear Medicine
- Cardiovascular Imaging
- Hematology
Background:
- Multigated acquisition (MUGA) scans assess left ventricular ejection fraction and wall motion.
- Abnormal tracer distribution in MUGA studies necessitates further investigation.
- Thalassemia can cause bone marrow hyperplasia.
Purpose of the Study:
- To report the utility of MUGA scans in identifying extramedullary hematopoiesis.
- To demonstrate scintigraphic evidence of bone marrow hyperplasia in a thalassemia patient.
Main Methods:
- Technetium-99m labeled red blood cell (RBC) gated blood pool ventriculography (MUGA) study.
- Analysis of planar images for abnormal tracer distribution.
Main Results:
- Significant tracer uptake observed in the rib cage of a young thalassemia patient.
- This uptake indicated scintigraphic evidence of bone marrow hyperplasia.
Conclusions:
- MUGA scans can reveal scintigraphic evidence of bone marrow hyperplasia.
- Abnormal tracer distribution in MUGA studies may indicate extramedullary hematopoiesis, as seen in thalassemia.
