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Serum nitric oxide levels in patients with coronary artery ectasia

Adalet Gürlek1, Kerim Esenboğa2, Özgür Ulaş Özcan1

  • 1Department of Cardiology, Faculty of Medicine, Ankara University, Ankara-Turkey.

Anatolian Journal of Cardiology
|May 6, 2016
PubMed

Insights

This study found significantly lower serum nitric oxide (NO) levels in patients with coronary artery ectasia (CAE). These findings suggest that reduced NO may contribute to the development of CAE.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Atherosclerosis is linked to decreased nitric oxide (NO) levels.
  • Endothelial dysfunction and atherosclerosis are potential causes of coronary artery ectasia (CAE).

Purpose of the Study:

  • To investigate the relationship between serum NO levels and CAE.
  • To determine if NO levels are a risk factor for CAE development.

Main Methods:

  • A prospective controlled study compared 40 CAE patients with 40 controls.
  • Serum NO levels were measured and analyzed using logistic regression and ROC curves.
  • Exclusion criteria included stenotic plaques, slow flow, prior revascularization, acute coronary syndromes, and other cardiovascular conditions.

Main Results:

  • Serum NO concentrations were significantly lower in CAE patients (42.1±20.1 µmol/L) versus controls (77.3±15.7 µmol/L).
  • Low NO levels (OR=0.88) and LDL levels were independent factors associated with CAE.
  • A NO cut-off of 63.3 µmol/L predicted CAE with 87.5% sensitivity and 90% specificity.

Conclusions:

  • Decreased serum NO levels are associated with CAE.
  • This supports the hypothesis that reduced NO contributes to the pathogenesis of CAE.
Abstract

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