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A gene homologous to plasminogen located on human chromosome 2q11-p11
S L Frank1, I Klisak, R S Sparkes
1Department of Microbiology, School of Medicine, University of California, Los Angeles 90024.
Genomics
|April 1, 1989
Abstract:
A plasminogen probe encoding kringles 1-3 detects homologous loci on human chromosomes 6 and 2 by somatic cell hybrid analysis. Regional localization by in situ hybridization places the loci at 6q26-27 and 2p11-q11. Further analysis by varying washing stringencies of hybridization filters reveals a greater homology with the chromosome 6 locus than with the chromosome 2 locus. These results confirm localization of the plasminogen gene to human chromosome 6q26-27 and indicate that a homologous sequence of unknown identity resides on chromosome 2p11-q11.