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Probiotics01:22

Probiotics

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Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
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The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
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Probiotics and Atopic Dermatitis: An Overview.

Irfan A Rather1, Vivek K Bajpai1, Sanjay Kumar2

  • 1Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University Gyeongsan, South Korea.

Frontiers in Microbiology
|May 6, 2016
PubMed
Summary

Probiotics may offer benefits for atopic dermatitis (AD) treatment, but effectiveness depends on strain, timing, and dosage. More research is needed to confirm their clinical use for this chronic inflammatory skin condition.

Keywords:
atopic dermatitisclinical trialsinflammationprobioticsskin diseases

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Area of Science:

  • Dermatology
  • Immunology
  • Microbiology

Background:

  • Atopic dermatitis (AD) is a prevalent, chronic inflammatory skin disease with increasing incidence globally.
  • AD imposes significant economic and social burdens, driving research into prevention and treatment strategies.
  • Current research explores the potential role of probiotics in managing AD, though evidence remains inconclusive.

Purpose of the Study:

  • To review current understanding of atopic dermatitis pathogenesis.
  • To evaluate the existing evidence on the efficacy of probiotics in AD prevention and treatment.
  • To discuss factors influencing probiotic effectiveness in AD management.

Main Methods:

  • Literature review of studies investigating probiotics and atopic dermatitis.
  • Analysis of factors such as probiotic strains, administration timing, duration, and dosage.
  • Examination of mechanisms underlying AD development and potential probiotic interactions.

Main Results:

  • Evidence suggests probiotics may positively influence AD treatment, but effects are strain- and context-dependent.
  • Key factors influencing outcomes include specific probiotic strains, onset time, duration of exposure, and dosage.
  • Currently, robust clinical evidence to support widespread probiotic use for AD is lacking.

Conclusions:

  • The role of probiotics in atopic dermatitis management requires further investigation.
  • More research is needed to establish clear guidelines for probiotic use in AD.
  • Understanding the interplay between AD pathophysiology and probiotic interventions is crucial for future clinical applications.