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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Immunometabolism in Tuberculosis.

Lanbo Shi1, Eliseo A Eugenin1, Selvakumar Subbian1

  • 1Public Health Research Institute, New Jersey Medical School, Biomedical and Health Sciences, Rutgers - The State University of New Jersey , Newark, NJ , USA.

Frontiers in Immunology
|May 6, 2016
PubMed
Summary
This summary is machine-generated.

Immune cells shift to glycolysis (Warburg effect) during infection, crucial for fighting pathogens. Mycobacterium tuberculosis may exploit this metabolic change to persist in the host.

Keywords:
granulomahypoxia-inducible factor 1 alphaimmune responsemetabolismthe Warburg effecttuberculosis

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Area of Science:

  • Immunometabolism
  • Cellular metabolism
  • Infectious disease immunology

Background:

  • Immune cell activation involves metabolic reprogramming, notably the Warburg effect (glycolysis dominance).
  • The Warburg effect is essential for producing antimicrobial and pro-inflammatory molecules during infection.

Purpose of the Study:

  • To review the Warburg effect in host immune responses to tuberculosis (TB).
  • To explore mechanisms regulating the Warburg effect, including HIF-1α.
  • To propose Mtb's manipulation of the Warburg effect for its survival.

Main Methods:

  • Literature review and synthesis of current research on immunometabolism and TB.
  • Analysis of the role of hypoxia-inducible factor 1 alpha (HIF-1α) in regulating the Warburg effect.
  • Hypothesis generation regarding Mtb's interaction with immune cell metabolism.

Main Results:

  • The Warburg effect is a key metabolic adaptation in immune cells during infection.
  • HIF-1α is a critical regulator of the Warburg effect and cellular stress responses.
  • Mtb may interfere with the Warburg effect to establish persistent infection.

Conclusions:

  • Understanding immunometabolic shifts during TB is vital for developing novel therapies.
  • Targeting the Warburg effect could enhance Mtb clearance and reduce drug resistance.