Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exocytosis00:50

Exocytosis

10.0K
Exocytosis is a process that releases molecules outside the cell. Like other bulk transport mechanisms, exocytosis requires energy.
Exocytosis is the opposite of endocytosis, which brings molecules inside the cell. Sometimes, the released materials are signaling molecules. For example, neurons typically use exocytosis to release neurotransmitters. Cells also use exocytosis to insert proteins such as ion channels into their cell membranes, secrete proteins for use in the extracellular matrix, or...
10.0K
Exocytosis00:51

Exocytosis

75.0K
Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.
75.0K
Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis01:18

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

4.3K
Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell...
4.3K
Overview of Exosomes01:36

Overview of Exosomes

3.9K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.9K
Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

7.7K
Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
7.7K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

5.1K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis and Characterization of Di- and Tetrapropargyl Derivatives of (+)-Catechin: Evaluation of Their Potential Antimalarial Activity Through In Vitro and In Silico Approaches.

Chemistry & biodiversity·2026
Same author

Antibacterial Surfaces Prepared through Electropolymerization of <i>N</i>-Heterocyclic Carbene Complexes: A Pivotal Role of the Metal.

ACS applied bio materials·2025
Same author

The ER-PM interaction is essential for cytokinesis and recruits the actin cytoskeleton through the SCAR/WAVE complex.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Coordination Assemblies of Acetylenic Dithioether Ligands on Silver(I) Salts: Crystal Structure, Antibacterial and Cytotoxicity Activities.

Inorganic chemistry·2024
Same author

The trichothecene mycotoxin deoxynivalenol facilitates cell-to-cell invasion during wheat-tissue colonization by Fusarium graminearum.

Molecular plant pathology·2024
Same author

An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis.

Proceedings of the National Academy of Sciences of the United States of America·2024

Related Experiment Video

Updated: Mar 21, 2026

Imaging FITC-dextran as a Reporter for Regulated Exocytosis
04:50

Imaging FITC-dextran as a Reporter for Regulated Exocytosis

Published on: June 20, 2018

13.5K

The Exocyst Complex in Health and Disease.

Magdalena Martin-Urdiroz1, Michael J Deeks1, Connor G Horton1

  • 1Biosciences, College of Life and Environmental Sciences, University of Exeter Exeter, UK.

Frontiers in Cell and Developmental Biology
|May 6, 2016
PubMed
Summary
This summary is machine-generated.

The exocyst complex, crucial for vesicle fusion during exocytosis, also directs membrane growth in diverse organisms. This review explores its roles in cell polarity, signaling, and communication, impacting health and disease.

Keywords:
exocyst complexfungimammalspathogensplants

More Related Videos

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
10:21

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

Published on: September 16, 2020

6.6K
Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans
09:06

Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans

Published on: September 18, 2020

8.1K

Related Experiment Videos

Last Updated: Mar 21, 2026

Imaging FITC-dextran as a Reporter for Regulated Exocytosis
04:50

Imaging FITC-dextran as a Reporter for Regulated Exocytosis

Published on: June 20, 2018

13.5K
Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
10:21

Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

Published on: September 16, 2020

6.6K
Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans
09:06

Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans

Published on: September 18, 2020

8.1K

Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Exocytosis is a fundamental cellular process involving vesicle fusion with the plasma membrane.
  • This process releases extracellular material, delivers membrane proteins, and contributes lipids for membrane expansion.
  • The exocyst complex, an evolutionarily conserved octameric protein assembly, mediates vesicle tethering before plasma membrane fusion.

Purpose of the Study:

  • To review the multifaceted functions of the exocyst complex beyond its established role in secretion.
  • To explore the exocyst complex's involvement in cell polarity, signaling, and cell-cell communication.
  • To discuss the implications of exocyst complex functions in plant and animal health and disease.

Main Methods:

  • Literature review of recent findings on exocyst complex functions.
  • Synthesis of knowledge regarding exocyst complex roles in various biological systems.
  • Analysis of the convergence of exocyst complex functions in membrane growth directionality.

Main Results:

  • The exocyst complex is implicated in diverse intracellular processes beyond secretion.
  • These functions collectively contribute to defining membrane growth directionality across species.
  • Evidence suggests exocyst complex involvement in cell polarity, signaling, and intercellular communication.

Conclusions:

  • The exocyst complex plays a critical, conserved role in directing membrane growth.
  • Its functions extend to fundamental cellular processes influencing cell polarity and communication.
  • Understanding exocyst complex mechanisms is vital for addressing plant and animal health and disease.