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Association of genetic polymorphism and external apical root resorption
The Angle Orthodontist
|May 6, 2016
Summary
Genetic polymorphism
Area of Science:
- Genetics
- Orthodontics
- Periodontology
Background:
- External apical root resorption (EARR) is a common complication of orthodontic treatment.
- The role of genetic factors in EARR is not fully understood.
Purpose of the Study:
- To systematically review and evaluate the existing literature on the association between genetic polymorphism and EARR.
Main Methods:
- A comprehensive literature search was conducted across multiple databases (MEDLINE, Embase, Cochrane, PubMed).
- Two independent reviewers screened studies, and bibliographies were manually searched.
- Thirteen studies met the inclusion criteria for the review.
Main Results:
- Four studies were classified as low-quality, while nine were deemed high-quality.
- The included studies presented conflicting findings regarding the association between genetic polymorphism and EARR.
Conclusions:
- Current evidence is inconclusive on whether genetic polymorphism influences EARR.
- Future research requires standardized methodologies, larger sample sizes, and robust statistical reporting to clarify this relationship.
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