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Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
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Elastomeric PGS Scaffolds in Arterial Tissue Engineering
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Elastomers in vascular tissue engineering.

Matti A Hiob1, Gareth W Crouch2, Anthony S Weiss3

  • 1School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia; Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.

Current Opinion in Biotechnology
|May 6, 2016
PubMed
Summary
This summary is machine-generated.

Elastomers are key in vascular engineering for creating compliant implants that integrate with the body. Recent advancements focus on resorbable elastomers to support tissue regeneration in cardiovascular treatments.

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Area of Science:

  • Biomaterials Science
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Elastomers are widely used in vascular engineering due to their ability to match native tissue compliance.
  • This compliance promotes integration and repair, unlike rigid materials that can cause adverse physiological responses.
  • The field is shifting towards temporary, resorbable elastomers for tissue regeneration.

Purpose of the Study:

  • To review the latest developments in synthetic and natural elastomers.
  • To highlight their applications in cardiovascular treatments.
  • To discuss how material design controls behavior, bioactivity, and biocompatibility.

Main Methods:

  • Review of recent literature on elastomer synthesis and characterization.
  • Analysis of studies on elastomer applications in cardiovascular devices.
  • Evaluation of techniques for controlling material properties and bioactivity.

Main Results:

  • Elastomer design has evolved from permanent to resorbable implants.
  • Controlled chemistries and processing enhance material behavior, bioactivity, and in vivo biocompatibility.
  • Significant progress has been made in applying these elastomers to cardiovascular therapies.

Conclusions:

  • Elastomers are crucial for developing advanced vascular implants.
  • Resorbable elastomers offer promising strategies for tissue regeneration.
  • Continued innovation in elastomer design is vital for future cardiovascular treatments.