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Chelation therapy to treat atherosclerosis, particularly in diabetes: is it time to reconsider?

Gervasio A Lamas1, Ian Ergui1

  • 1a The Columbia University Division of Cardiology at Mount Sinai Medical Center , Miami Beach , FL , USA.

Expert Review of Cardiovascular Therapy
|May 6, 2016
PubMed

Insights

Chelation therapy shows promise in reducing cardiovascular events, especially in patients with diabetes post-myocardial infarction. Further research through TACT2 will explore these benefits in a targeted population.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Trials
  • Pharmacology

Background:

  • Previous case reports suggested chelation therapy benefits atherosclerotic disease.
  • Small trials lacked power for conclusive evidence on clinical outcomes.

Purpose of the Study:

  • To present results from the Trial to Assess Chelation Therapy (TACT).
  • To discuss future research directions, including the TACT2 trial.

Main Methods:

  • The Trial to Assess Chelation Therapy (TACT) was a sufficiently powered randomized trial.
  • Focus on clinical endpoints and patient subgroups, including those with diabetes.

Main Results:

  • Chelation therapy reduced adverse cardiovascular events in post-myocardial infarction patients.
  • Diabetic patients showed enhanced benefit: 41% relative risk reduction (NNT=6.5 over 5 years).
  • Results influenced ACC/AHA guidelines, changing chelation therapy classification.

Conclusions:

  • Chelation therapy demonstrates a significant benefit for cardiovascular events, particularly in diabetic patients post-MI.
  • The TACT2 trial will further investigate these effects in diabetic patients with prior myocardial infarction.
Abstract

Keywords:
Myocardial infarctionchelationdiabetes mellitusedetate disodiumsecondary prevention

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