Related Experiment Video
Updated: Mar 21, 2026
09:58
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
4.1K
Relation between plasma and brain lipids
Cheryl L Wellington1, Ruth Frikke-Schmidt
1aDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada bDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospitals cFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Current Opinion in Lipidology
|May 6, 2016
Summary
Low levels of apolipoprotein E strongly predict dementia, while other apolipoproteins may serve as future biomarkers for neurodegenerative diseases. Cholesterol-lowering treatments
Area of Science:
- Neuroscience
- Biochemistry
- Genetics
Background:
- Lipids, lipoproteins, and apolipoproteins are implicated in neurodegenerative diseases.
- Understanding their role in brain health is crucial for disease prevention and treatment.
Purpose of the Study:
- Evaluate evidence on lipids, lipoproteins, and apolipoproteins in neurodegenerative diseases.
- Review the impact of cholesterol-lowering treatments on cognitive function.
Main Methods:
- Analysis of experimental data.
- Review of human studies and clinical literature.
Main Results:
- Plasma lipid levels lack consistent dementia risk association.
- Low apolipoprotein E levels predict dementia via unknown mechanisms.
- Brain and cerebrospinal fluid apolipoproteins show neuroprotective roles.
Conclusions:
- Apolipoproteins involved in peripheral lipid metabolism may impact brain vascular health and Alzheimer's disease.
- Further research on central nervous system apolipoproteins could identify new dementia biomarkers and drug targets.
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