Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inhibitors of Viral Protein Synthesis

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma.

Cell reports·2025

Same author

Author Correction: Brahma safeguards canalization of cardiac mesoderm differentiation.

Nature·2025

Same author

Single-cell RNA sequencing algorithms underestimate changes in transcriptional noise compared to single-molecule RNA imaging.

Cell reports methods·2024

Same author

Quantitative comparison of single-cell RNA sequencing versus single-molecule RNA imaging for quantifying transcriptional noise.

bioRxiv : the preprint server for biology·2024

Same author

Engineered deletions of HIV replicate conditionally to reduce disease in nonhuman primates.

Science (New York, N.Y.)·2024

Same author

Expression of thioredoxin-1 in the ASJ neuron corresponds with and enhances intrinsic regenerative capacity under lesion conditioning in C. elegans.

FEBS letters·2023

Search research articles

Related Experiment Video

Updated: Mar 21, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

Exploiting Genetic Interference for Antiviral Therapy.

Elizabeth J Tanner¹, Karla A Kirkegaard², Leor S Weinberger^1,3

¹Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America.

|May 6, 2016

Summary

This summary is machine-generated.

Viral evolution poses a significant health threat. This study explores using genetic interference, via dominant drug targeting and therapeutic interfering particles, to combat drug resistance and improve antiviral therapies, especially in resource-limited settings.

More Related Videos

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

Related Experiment Videos

Last Updated: Mar 21, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

Area of Science:

Virology
Molecular Biology
Genetics

Background:

Rapidly evolving viruses like influenza, HIV, and Ebola are major health threats.
Viral mutational escape through error-prone replication leads to drug resistance.
Viral population heterogeneity can cause genetic interference, reducing viral fitness.

Purpose of the Study:

To discuss antiviral strategies that exploit genetic interference.
To address challenges in combating viral drug resistance and targeting therapy in resource-poor settings.

Main Methods:

Exploiting inherent viral genetic diversity.
Generating de novo interference by engineering competing viral genomes.
Discussing dominant drug targeting and therapeutic interfering particles.

Main Results:

Genetic interference can be a powerful tool against viral evolution.
Antiviral strategies can overcome drug resistance.
Therapeutic interventions can be better targeted to high-risk populations.

Conclusions:

Exploiting genetic interference offers a novel approach to antiviral therapy.
Dominant drug targeting and therapeutic interfering particles show promise in overcoming viral resistance.
These strategies can improve treatment efficacy in resource-limited settings.